The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.

  title={The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.},
  author={Xin Wang and Ana C. Sirianni and Zhijuan Pei and Kerry A. Cormier and Karen Vail Smith and Jiying Jiang and Shuanhu Zhou and Hui Wang and Rong Zhao and Hiroko Yano and Jeong Eun Kim and Wei Li and Bruce S. Kristal and Robert Ferrante and Robert Max Friedlander},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={31 41},
Melatonin mediates neuroprotection in several experimental models of neurodegeneration. It is not yet known, however, whether melatonin provides neuroprotection in genetic models of Huntington's disease (HD). We report that melatonin delays disease onset and mortality in a transgenic mouse model of HD. Moreover, mutant huntingtin (htt)-mediated toxicity in cells, mice, and humans is associated with loss of the type 1 melatonin receptor (MT1). We observe high levels of MT1 receptor in… CONTINUE READING


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