The melanopsin system: Phototransduction, projections, functions, and clinical implications.

@article{Benarroch2011TheMS,
  title={The melanopsin system: Phototransduction, projections, functions, and clinical implications.},
  author={Eduardo E. Benarroch},
  journal={Neurology},
  year={2011},
  volume={76 16},
  pages={
          1422-7
        }
}
The melanopsin system consists of retinal ganglion cells containing the photopigment melanospin, which are directly activated by light in the absence of inputs from the photoreceptors. These intrinsically photosensitive retinal ganglion cells (ipRGCs) detect environmental brightness; combine their direct, melanospin-triggered photoresponses with signals derived from rods and cones; and project to several targets in the diencephalon and midbrain. Via these projections, the melanospin system… CONTINUE READING

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