The melanocortin 4 receptor mediates leptin stimulation of luteinizing hormone and prolactin surges in steroid-primed ovariectomized rats.

@article{Watanobe1999TheM4,
  title={The melanocortin 4 receptor mediates leptin stimulation of luteinizing hormone and prolactin surges in steroid-primed ovariectomized rats.},
  author={Hajime Watanobe and Helgi B. Schi{\"o}th and Jarl E. S. Wikberg and Takane Suda},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={257 3},
  pages={860-4}
}
We have previously reported that leptin, the product of the obese (ob) gene, may play a physiologically relevant role in the generation of estradiol/progesterone-induced luteinizing hormone (LH) and prolactin (PRL) surges in female rats. In the present study, we examined whether the stimulatory effect of leptin on the hormonal surges is mediated through the melanocortin (MC) 4 receptor in the brain, as is leptin's effect on feeding behavior. We also explored whether the MC4 receptor… CONTINUE READING

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