The melanocortin-4 receptor integrates circadian light cues and metabolism.

@article{Arble2015TheMR,
  title={The melanocortin-4 receptor integrates circadian light cues and metabolism.},
  author={D. Arble and J. Holland and N. Ottaway and J. Sorrell and Joshua W. Pressler and Rachel L. Morano and S. Woods and R. Seeley and J. Herman and D. Sandoval and D. P{\'e}rez-Tilve},
  journal={Endocrinology},
  year={2015},
  volume={156 5},
  pages={
          1685-91
        }
}
The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer, summer days, suggesting an underlying link between circadian biology and the melanocortin system. Despite key neuroanatomical substrates shared by both circadian and melanocortin-signaling pathways, little is known about the relationship between… Expand
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