The melanin-concentrating hormone system modulates cocaine reward.

@article{Chung2009TheMH,
  title={The melanin-concentrating hormone system modulates cocaine reward.},
  author={Shinjae Chung and Frederic Woodward Hopf and Hiroshi Nagasaki and Chun-ying Li and James D. Belluzzi and Antonello Bonci and Olivier Civelli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 16},
  pages={6772-7}
}
Drug addiction is mediated by complex neuronal processes that converge on the shell of the nucleus accumbens (NAcSh). The NAcSh receives inputs from the lateral hypothalamus (LH), where self-stimulation can be induced. Melanin-concentrating hormone (MCH) is produced mainly in the LH, and its receptor (MCH1R) is highly expressed in the NAcSh. We found that, in the NAcSh, MCH1R is coexpressed with dopamine receptors (D1R and D2R), and that MCH increases spike firing when both D1R and D2R are… CONTINUE READING

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