The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo.

@article{Kemp2002TheMH,
  title={The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo.},
  author={E Helen Kemp and Elizabeth A Waterman and Brian E. Hawes and Kim O'neill and Raju V S R K Gottumukkala and David J. Gawkrodger and Anthony P. Weetman and Philip F. Watson},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={109 7},
  pages={923-30}
}
Vitiligo is a common depigmenting disorder resulting from the loss of melanocytes in the skin. The pathogenesis of the disease remains obscure, although autoimmune mechanisms are thought to be involved. Indeed, autoantibodies and autoreactive T lymphocytes that target melanocytes have been reported in some vitiligo patients. The objective of this study was to identify pigment cell antigens that are recognized by autoantibodies in vitiligo. Using IgG from vitiligo patients to screen a melanocyte… CONTINUE READING
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