The mediator for stringent control, ppGpp, binds to the beta-subunit of Escherichia coli RNA polymerase.

Abstract

BACKGROUND Inhibition of transcription of rRNA in Escherichia coli upon amino acid starvation is thought to be due to the binding of ppGpp to RNA polymerase. However, the nature of this interaction still remains obscure. RESULTS Here, the azido-derivative of ppGpp was synthesized from azido-GDP and [gamma-32P]ATP by way of the phosphate transfer reaction… (More)

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