The medial temporal lobe.

@article{Squire2004TheMT,
  title={The medial temporal lobe.},
  author={Larry R. Squire and Craig E. L. Stark and Robert E. Clark},
  journal={Annual review of neuroscience},
  year={2004},
  volume={27},
  pages={
          279-306
        }
}
The medial temporal lobe includes a system of anatomically related structures that are essential for declarative memory (conscious memory for facts and events). The system consists of the hippocampal region (CA fields, dentate gyrus, and subicular complex) and the adjacent perirhinal, entorhinal, and parahippocampal cortices. Here, we review findings from humans, monkeys, and rodents that illuminate the function of these structures. Our analysis draws on studies of human memory impairment and… Expand
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TLDR
The bilateral posterior posterior PHC is found to participate in encoding of both the object associated with a location and the location associated with an object, which is in contrast to previous work which found that activity in an area in the left anterior PHC and the right anterior MTL was only correlated with the memory for the location related to an object. Expand
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TLDR
It is argued that little or no conclusive evidence currently exists to support the view that the medial temporal lobe is not only important for memory, but also critical for certain forms of perception, and that extraneous damage to extra-MTL areas may underlie the reported perceptual deficits in the group of amnesic patients. Expand
A familiarity signal in human anterior medial temporal cortex?
TLDR
It is reported that experimentally familiar items elicit smaller hemodynamic responses in human anterior MTL, consistent with the findings from nonhuman primates. Expand
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TLDR
The role of the hippocampus and neocortex and its surrounding medial temporal lobe structures in memory consolidation is described: a process in which novel memories become integrated into long-term memory. Expand
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TLDR
A growing body of evidence is converging on a functional organization of the cortical, subcortical, and MTL structures that support the fundamental features of episodic memory in humans and animals. Expand
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References

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TLDR
It is suggested that, whereas damage to the hippocampal region produces measurable memory impairment, a substantial part of the severe memory impairment produced by large medial temporal lobe lesions in humans and monkeys can be attributed to damage to entorhinal, perirHinal, and parahippocampal cortices adjacent to the hippocampusal region. Expand
A familiarity signal in human anterior medial temporal cortex?
TLDR
It is reported that experimentally familiar items elicit smaller hemodynamic responses in human anterior MTL, consistent with the findings from nonhuman primates. Expand
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TLDR
The medial temporal lobe memory system is needed to bind together the distributed storage sites in neocortex that represent a whole memory, but the role of this system is only temporary, as time passes after learning, memory stored in neoc cortex gradually becomes independent of medialporal lobe structures. Expand
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The medial temporal lobe is indispensable for normal memory processing in both human and non-human primates, as is shown by the fact that large lesions in it produce a severe impairment in theExpand
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TLDR
Cross‐species comparisons show that the patterns of mnemonic activity observed throughout the medial temporal lobe are largely conserved across species and show that neurons in each of the medialporal lobe areas can perform both similar as well as distinctive mnemon functions. Expand
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TLDR
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TLDR
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TLDR
This work used event-related functional MRI to examine the relation between activation in distinct medial temporal lobe subregions during memory formation and the ability to later recognize an item as previously encountered and later recollect specific contextual details about the prior encounter. Expand
Memory for places learned long ago is intact after hippocampal damage
TLDR
The results show that the medialporal lobe is not the permanent repository of spatial maps, and support the view that the hippocampus and other structures in the medial temporal lobe are essential for the formation of long-term declarative memories, both spatial and non-spatial, but not for the retrieval of very remote memories. Expand
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