The medial temporal lobe memory system

@article{Squire1991TheMT,
  title={The medial temporal lobe memory system},
  author={Lr. Squire and Stuart M. Zola-Morgan},
  journal={Science},
  year={1991},
  volume={253},
  pages={1380 - 1386}
}
Studies of human amnesia and studies of an animal model of human amnesia in the monkey have identified the anatomical components of the brain system for memory in the medial temporal lobe and have illuminated its function. This neural system consists of the hippocampus and adjacent, anatomically related cortex, including entorhinal, perirhinal, and parahippocampal cortices. These structures, presumably by virtue of their widespread and reciprocal connections with neocortex, are essential for… 
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These findings show that, first, the hippocampal region itself is essential for normal memory function; and second, the adjacent entorhinal and parahippocampal cortices, either alone or in combination, are also an essential component of the medial temporal lobe memory system.
The possible contribution of the amygdala to memory.
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References

SHOWING 1-10 OF 173 REFERENCES
The neuroanatomy of amnesia. A critique of the hippocampal memory hypothesis.
  • J. A. Horel
  • Biology, Psychology
    Brain : a journal of neurology
  • 1978
TLDR
The discovery that medial temporal lobe lesions produce amnesia in humans if the lesion extends sufficiently far posteriorly to include the hippocampus forms the keystone of the hippocampal memory hypothesis, which concludes that the animal model is a poor one.
The neuropsychology of human memory.
  • L. Squire
  • Psychology, Biology
    Annual review of neuroscience
  • 1982
In agreement with the neuropsychological findings, available anatomical data from patients with diencephalic or bitemporal amnesia suggest that these amnesias need not result from damage to a single
The neuroanatomy of amnesia: amygdala-hippocampus versus temporal stem.
TLDR
The results indicate that the hippocampus, amygdala, or both, but not the temporal stem, are involved in memory in the monkey and suggest that a rapprochement between the findings for the human and the nonhuman primate may be close at hand.
A memory system in the monkey.
  • M. Mishkin
  • Biology, Psychology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1982
A neural model is presented, based largely on evidence from studies in monkeys, postulating that coded representation of stimuli are stored in the higher-order sensory (i.e. association) areas of the
Lesions of the hippocampal formation but not lesions of the fornix or the mammillary nuclei produce long-lasting memory impairment in monkeys
A group of tasks sensitive to human amnesia were used to characterize the severity and duration of memory impairment in monkeys following bilateral damage to the hippocampal formation, fornix, or
Independence of memory functions and emotional behavior: Separate contributions of the hippocampal formation and the amygdala
TLDR
Findings show that memory impairment and abnormal emotional behavior are anatomically dissociable and independent effects of damage to the medial temporal lobe.
Hippocampus, space, and memory
TLDR
It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.
Hippocampal resections impair associative learning and recognition memory in the monkey
TLDR
Though monkeys in the hippocampal group were impaired on both delays and lists, the impairment was more severe on the lists, with abnormal sensitivity to pro- and retroactive interference as a possible source of difficulty.
Lesions of perirhinal and parahippocampal cortex that spare the amygdala and hippocampal formation produce severe memory impairment
TLDR
It is suggested that the severe memory impairment in monkeys and humans associated with bilateral medial temporal lesions results from damage to the hippocampal formation and adjacent, anatomically related cortex, not from conjoint hippocampus-amygdala damage.
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