The medial temporal lobe and recognition memory.

  title={The medial temporal lobe and recognition memory.},
  author={Howard Eichenbaum and Andrew P. Yonelinas and Charan Ranganath},
  journal={Annual review of neuroscience},
The ability to recognize a previously experienced stimulus is supported by two processes: recollection of the stimulus in the context of other information associated with the experience, and a sense of familiarity with the features of the stimulus. Although familiarity and recollection are functionally distinct, there is considerable debate about how these kinds of memory are supported by regions in the medial temporal lobes (MTL). Here, we review evidence for the distinction between… 

Figures and Tables from this paper

Recollection and familiarity in the human thalamus
The role of the human hippocampus in familiarity-based and recollection-based recognition memory
Imaging recollection and familiarity in the medial temporal lobe: a three-component model
The human hippocampus contributes to both the recollection and familiarity components of recognition memory
High-frequency activity is measured in subjects undergoing direct brain recordings and found that hippocampal HFA dissociated based on both the stimulus evidence presented and the response choice, indicating that the hippocampus supports both the recollection and familiarity processes.
The medial temporal lobe and the attributes of memory
The role of the hippocampus in recognition memory
  • C. Bird
  • Psychology, Biology
  • 2017
Neural correlates of recognition memory for complex visual stimuli in the medial temporal lobe
Three experiments were designed to compare competing models of MTL function by measuring, using functional magnetic resonance imaging, the neural correlates of successful recollection- and familiarity-based memory judgements for different types of complex visual stimuli, consistent with views that the perirhinal cortex and hippocampus are differentially involved in processing objects and scenes, rather than in supporting distinct kinds of memory process.
Memory function and the hippocampus.
  • B. Opitz
  • Biology, Psychology
    Frontiers of neurology and neuroscience
  • 2014
A more complete picture of the importance of the hippocampus for declarative memories can only be drawn when the interactions of the medial temporal lobe with other brain areas are also taken into account.


Effects of Unilateral Prefrontal Lesions on Familiarity, Recollection, and Source Memory
It is suggested that the PFC plays a critical role in recognition memory based on familiarity as well as recollection and that left PFC regions are critical for source recollection.
Triple dissociation in the medial temporal lobes: recollection, familiarity, and novelty.
This is the first study to reveal a triple dissociation within the MTL associated with distinct retrieval processes, and this finding has direct implications for current memory models.
Separating the Brain Regions Involved in Recollection and Familiarity in Recognition Memory
The neural substrates of recognition memory retrieval were examined in a functional magnetic resonance imaging study to separate activity related to recollection from that related to continuous variations in familiarity, indicating that recollection cannot be attributed to familiarity strength.
A familiarity signal in human anterior medial temporal cortex?
It is reported that experimentally familiar items elicit smaller hemodynamic responses in human anterior MTL, consistent with the findings from nonhuman primates.
Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories
This work used event-related functional MRI to examine the relation between activation in distinct medial temporal lobe subregions during memory formation and the ability to later recognize an item as previously encountered and later recollect specific contextual details about the prior encounter.
Functional-Neuroanatomic Correlates of Recollection: Implications for Models of Recognition Memory
Results revealed that multiple left prefrontal cortical regions were engaged during attempts to recollect previous contextual details, regardless of the nature of the to-be-recollected details and of source recollection outcome (successful vs unsuccessful).
Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans
A functional magnetic resonance imaging study to compare the medial temporal lobe responses to changes in object identity and spatial configurations of objects found evidence for the predicted distinction between hippocampal and perirhinal cortical activations, although part of the hippocampus was also activated by identification of novel objects.
Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex.
With this task, it is demonstrated that rats have a visual memory profile, which is analogous to that in primates and depends on the function of perirhinal cortex, and it is found that selective lesions of hippocampus impair delay-dependent visual memory with a profile different from that produced by damage to the perirHinal cortex.