The medial hypothalamic defensive system: Hodological organization and functional implications

@article{Canteras2002TheMH,
  title={The medial hypothalamic defensive system: Hodological organization and functional implications},
  author={Newton Sabino Canteras},
  journal={Pharmacology Biochemistry and Behavior},
  year={2002},
  volume={71},
  pages={481-491}
}
  • N. Canteras
  • Published 1 March 2002
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
The hypothalamus is a relatively small division of the vertebrate forebrain that plays especially important roles in neural mechanisms assuring homeostasis, defense, and reproduction. Previous studies from our laboratory have suggested a distinct circuit in the medial hypothalamic zone as critically involved in the organization of innate defensive behavior. Thus, after exposure to a natural predator known to elicit innate defensive responses, increased Fos levels in the medial zone of the… Expand
View on Elsevier
doi.org
359 Citations
Highly Influential Citations
38
Background Citations
164
Methods Citations
5
Results Citations
6

359 Citations

Citation Type

Citation Type

Evidence for the thalamic targets of the medial hypothalamic defensive system mediating emotional memory to predatory threats
TLDR
Investigation of the role of the dorsal premammillary nucleus's main thalamic targets in both unconditioned and conditioned defensive behaviors suggests that the PMd seems to be critically involved in the emotional memory processing related to predator cues. Expand
A study of the catecholaminergic inputs to the dorsal premammillary nucleus
TLDR
Evidence suggests that the locus coeruleus is seemingly a part of the circuit responding to predatory threats, and, as shown by the present results, is the sole source of catecholaminergic inputs to the PMd, providing noradrenergic Inputs to the nucleus, which, by acting via beta adrenoceptor, seems to be critical for the expression of anti-predatory responses. Expand
Blockade of NMDA or NO in the dorsal premammillary nucleus attenuates defensive behaviors
TLDR
The results showed that both AP7 and NP significantly attenuated the behavioral responses induced by the live cat, suggesting that the NMDA/NO pathway plays an important role in the Behavioral responses mediated by the PMd. Expand
Dissecting the brain's fear system reveals the hypothalamus is critical for responding in subordinate conspecific intruders
TLDR
It is now clear that differentiable neural circuitry underlies defensive responses to fear conditioning associated with painful stimuli, predators, and dominant conspecifics and that the hypothalamus is an essential component of the circuitry for the latter two stimuli. Expand
Evidence of a Role for the Lateral Hypothalamic Area Juxtadorsomedial Region (LHAjd) in Defensive Behaviors Associated with Social Defeat
TLDR
A refined model for the neural circuits that are central to the control of socially-relevant defensive behaviors is outlined, and possible broader implications of these data for disorders of behavioral control are considered. Expand
Differential Encoding of Predator Fear in the Ventromedial Hypothalamus and Periaqueductal Grey
TLDR
Using single unit in vivo electrophysiological recordings in mice, neuronal populations in the medial hypothalamus and brainstem that encode defensive responses to a rat predator are identified and it is found that both structures encode both sensory as well as motor aspects of the behavior although with different kinetics. Expand
Differential encoding of predator fear in the ventromedial hypothalamus and periaqueductal grey
TLDR
Electrophysiological recordings of single units in behaving mice exposed to a rat are used to investigate the encoding of predator fear in the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey, suggesting a distributed encoding of sensory and motor features in the medial hypothalamic-brainstem instinctive network. Expand
Chapter 3.2 Neural systems activated in response to predators and partial predator stimuli
Abstract Interest in unconditioned anti-predator defenses has a long history and helps to portray a more complete view of the neural system mediating fear reactions under natural conditions. In this… Expand
The ventromedial hypothalamus mediates predator fear memory
TLDR
It is demonstrated that neural activity in the VMHdm is required for both the acquisition and recall of predator fear memory, whereas that of its downstream effector, the dorsal periaqueductal grey, is required only for the acute expression of fear. Expand
Lhx6 Delineates a Pathway Mediating Innate Reproductive Behaviors from the Amygdala to the Hypothalamus
TLDR
Using genetically encoded and conventional axonal tracers, the transcription factor Lhx6 delineates the reproductive branch of this pathway and a transcription factor family that may contribute to the development of this substrate is identified. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 84 REFERENCES
Severe Reduction of Rat Defensive Behavior to a Predator by Discrete Hypothalamic Chemical Lesions
TLDR
The dorsal premammillary nucleus showed the most striking increase in Fos levels, and cell body-specific chemical lesions therein virtually eliminated two major components of defensive behavior but increased exploratory behavior, suggesting that this caudal hypothalamic nucleus plays a critical role in the expression of behavioral responses sometimes critical for survival of the individual. Expand
The organization of the hypothalamic pathways mediating affective defense behavior in the cat
TLDR
It is concluded that the organization of the pathway mediating affective defense behavior from the ventromedial hypothalamus to the midbrain involves an initial synapse within the region of the anteromedia hypothalamus and a second synapse in the mid brain central gray substance. Expand
The dorsal premammillary nucleus: an unusual component of the mammillary body.
  • N. Canteras, L. Swanson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1992
TLDR
The results of anterograde and retrograde axonal transport experiments in the rat indicate that the dorsal premammillary nucleus gives rise to a branched pathway ending in the anterior thalamic group and brainstem, like the medial and lateral mammillary nuclei but without receiving a direct input from the columns of the fornix. Expand
Afferent connections of the dorsal premammillary nucleus
TLDR
By means of massive inputs from the ventral tegmental nucleus, the PMd is in a position to integrate information from a neural system involved in spatial working memory, which may be of particular relevance for an effect of attentional mechanisms on the selection of appropriate escape strategies. Expand
The structural organization of connections between hypothalamus and cerebral cortex 1 Published on the World Wide Web on 2 June 1997. 1
TLDR
Hypothalamic output is characterized by descending projections to brainstem and spinal motor systems, and by projections back to the cerebral cortex, which are both direct and via a continuous rostromedial part of the dorsal thalamus. Expand
The septal forebrain and the inhibitory modulation of attack and defense in the rat. A review.
TLDR
It is argued that most of the existing evidence can be accounted for if the septal forebrain region is considered to exert an independent inhibitory control over attack and defense. Expand
Fos expression in forebrain afferents to the hypothalamic paraventricular nucleus following swim stress
TLDR
The present experiment sought to identify forebrain areas potentially involved in afferent regulation of the PVN in response to an acute stressor and identified neural pathways mediating activation and inhibition of the hypothalamic‐pituitary‐adrenocortical axis. Expand
Organization of projections from the dorsomedial nucleus of the hypothalamus: A PHA‐L study in the rat
The axonal projections of the dorsomedial nucleus of the hypothalamus were investigated by using Phaseolous vulgaris‐leucoagglutinin. The main conclusion of this work is that these projections are… Expand
Alterations in behavioral responses to stressors following excitotoxin lesions of dorsomedial hypothalamic regions
TLDR
Results following IBO lesions indicate an altered responsiveness to sudden stressors, particularly as relates to novelty or exploration-oriented behaviors, which contributes to those that have begun to define neural interactions that are essential for integrated stress responses. Expand
Organization of projections from the anterior hypothalamic nucleus: A Phaseolus vulgaris‐leucoagglutinin study in the rat
TLDR
Anterior hypothalamic nucleus (AHN) projections were examined with the Phaseolus vulgaris‐leucoagglutinin (PHA‐L) method in adult male rats and the results are discussed in terms of neural circuitry that may be involved in mediating interactions between animals. Expand
...
1
2
3
4
5
...