The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains

@inproceedings{Desai2008TheMN,
  title={The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains},
  author={Salil D. Desai and Amy K Heffelfinger and Timothy M. Orcutt and Gary W. Litman and Jeffrey A Yoder},
  booktitle={BMC Evolutionary Biology},
  year={2008}
}
Novel immune-type receptor (NITR) genes are members of diversified multigene families that are found in bony fish and encode type I transmembrane proteins containing one or two extracellular immunoglobulin (Ig) domains. The majority of NITRs can be classified as inhibitory receptors that possess cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs). A much smaller number of NITRs can be classified as activating receptors by the lack of cytoplasmic ITIMs and presence of a… CONTINUE READING
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Khakoo SI: Speed and selection in the evolution of killer-cell immunoglobulin-like receptors

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