The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4.


Cells can respond to mechanical stress by gating mechanosensitive ion channels (MSCs). The cloning of Piezo1, a eukaryotic cation selective MSC, defines a new system for studying mechanical transduction at the cellular level. Because Piezo1 has electrophysiological properties similar to those of endogenous cationic MSCs that are selectively inhibited by the… (More)
DOI: 10.1021/bi200770q


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