The mechanobiology of mitral valve function, degeneration, and repair.

@article{Richards2012TheMO,
  title={The mechanobiology of mitral valve function, degeneration, and repair.},
  author={Jennifer M Richards and Emily J. Farrar and Bruce G. Kornreich and N Sydney Moїse and Jonathan T. Butcher},
  journal={Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology},
  year={2012},
  volume={14 1},
  pages={47-58}
}
In degenerative valve disease, the highly organized mitral valve leaflet matrix stratification is progressively destroyed and replaced with proteoglycan rich, mechanically inadequate tissue. This is driven by the actions of originally quiescent valve interstitial cells that become active contractile and migratory myofibroblasts. While treatment for myxomatous mitral valve disease in humans ranges from repair to total replacement, therapies in dogs focus on treating the consequences of the… CONTINUE READING
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