The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception.

@article{Nol2009TheMK,
  title={The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception.},
  author={Jacques No{\"e}l and Katharina Zimmermann and J{\'e}r{\^o}me Busserolles and Emanuel Deval and Abdelkrim Alloui and Sylvie Diochot and Nicolas Guy and Marc Borsotto and Peter Reeh and Alain Eschalier and Michel Lazdunski},
  journal={The EMBO journal},
  year={2009},
  volume={28 9},
  pages={1308-18}
}
The sensation of cold or heat depends on the activation of specific nerve endings in the skin. This involves heat- and cold-sensitive excitatory transient receptor potential (TRP) channels. However, we show here that the mechano-gated and highly temperature-sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated. They are important for the definition of temperature thresholds and temperature ranges in which… CONTINUE READING
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