The mechanisms of tolerance in antidepressant action

@article{Fava2011TheMO,
  title={The mechanisms of tolerance in antidepressant action},
  author={G. Fava and E. Offidani},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2011},
  volume={35},
  pages={1593-1602}
}
  • G. Fava, E. Offidani
  • Published 2011
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
There is increasing awareness that, in some cases, long-term use of antidepressant drugs (AD) may enhance the biochemical vulnerability to depression and worsen its long-term outcome and symptomatic expression, decreasing both the likelihood of subsequent response to pharmacological treatment and the duration of symptom-free periods. A review of literature suggesting potential side effects during long treatment with antidepressant drugs was performed. Studies were identified electronically… Expand
May antidepressant drugs worsen the conditions they are supposed to treat? The clinical foundations of the oppositional model of tolerance
  • G. Fava
  • Medicine
  • Therapeutic advances in psychopharmacology
  • 2020
TLDR
The oppositional model of tolerance provides a conceptual framework for weighing all these elements in the individual case and may explain loss of treatment efficacy during maintenance treatment and the fact that some side effects tend to occur only after a certain time. Expand
Selective Serotonin Reuptake Inhibitor Antidepressant Treatment Discontinuation Syndrome: A Review of the Clinical Evidence and the Possible Mechanisms Involved
TLDR
A comprehensive overview of the clinical evidence and the underlying pathophysiology of the SSRI discontinuation syndrome are discussed and the use of animal models is commented on to better understand this condition. Expand
A hormetic approach to understanding antidepressant effectiveness and the development of antidepressant tolerance - A conceptual view.
TLDR
A theoretical framework is developed for understanding how adaptations to SSRIs that restore synaptic homeostasis may partially contribute to their hormetic effects and rodent models show that serotonin neurotransmission to specific forebrain regions is a necessary, but insufficient cause of depressive symptoms. Expand
Efficacy and Tolerability of Benzodiazepines versus Antidepressants in Anxiety Disorders: A Systematic Review and Meta-Analysis
TLDR
The role and usefulness of BDZ need to be reappraised and no consistent evidence emerged supporting the advantage of using TCA over BDZ in treating generalized anxiety disorder, complex phobias and mixed anxiety-depressive disorders. Expand
An Oppositional Tolerance Account for Potential Cognitive Deficits Caused by the Discontinuation of Antidepressant Drugs.
TLDR
A novel framework based on the idea of allostatic adaptation is presented, which allows to predict how different antidepressants likely impair different cognitive processes as a result of withdrawal and rebound effects, and proposes drug-specific effects. Expand
Rational Use of Antidepressant Drugs
  • G. Fava
  • Medicine
  • Psychotherapy and Psychosomatics
  • 2014
TLDR
Clinical decisions concerned with the provision of knowledge to the individual patient need to be placed within the framework of risk (the likelihood of poor outcomes of an index disorder if the therapy is withheld), responsiveness to the treatment option, and vulnerability to the adverse effects of treatment. Expand
Antidepressant Withdrawal and Rebound Phenomena.
TLDR
A robust evidence base now indicates that there can be acute with- drawal phenomena when antidepressants are discontinued, and it is recommended that antidepressants should be tapered off over a period of more than four weeks. Expand
Understanding and Managing Withdrawal Syndromes After Discontinuation of Antidepressant Drugs.
TLDR
Alternative strategies that do not encompass continuation of antidepressant treatment are required, but there is currently lack of adequate research for guiding the clinical approach. Expand
The emergence of loss of efficacy during antidepressant drug treatment for major depressive disorder: An integrative review of evidence, mechanisms, and clinical implications
TLDR
The present review underscores the need to cautiously weight benefits and risks prior to considering long‐term antidepressant treatment for patients with MDD as tolerance may emerge in a subset of patients. Expand
Relapse prevention in recurrent major depressive disorder. A comparison of different treatment options based on clinical experience and a critical review of the literature
TLDR
A critical review of the literature of the main treatment options currently available to prevent relapse and recurrence in depression argued that the same solution may not apply to all patients and questioned the feasibility of a single course of treatment. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 153 REFERENCES
Can long-term treatment with antidepressant drugs worsen the course of depression?
  • G. Fava
  • Psychology, Medicine
  • The Journal of clinical psychiatry
  • 2003
TLDR
The possibility that antidepressant drugs may worsen the course of depression needs to be tested, even though its scientific exploration is likely to encounter considerable methodological and ideological difficulties. Expand
Tolerance in Antidepressant Treatment
TLDR
Observations are provided from their long-term collaborative study of outpatients with moderately severe, recurrent unipolar depression who relapsed during longterm treatment with (B)-fluoxetine, extending previous observations that increasing fluoxettine doses can rescue some late failures. Expand
Loss of antidepressant efficacy during maintenance therapy: possible mechanisms and treatments.
TLDR
Although several strategies have been proposed to overcome the loss of antidepressant efficacy, double-blind controlled studies are needed to ascertain the optimal strategy for this perplexing clinical problem. Expand
Evidence that patients with single versus recurrent depressive episodes are differentially sensitive to treatment discontinuation: a meta-analysis of placebo-controlled randomized trials.
TLDR
There is evidence, however, that with increasing number of episodes, patients develop a relative resistance against the prophylactic properties of antidepressant medication, regardless of a number of clinical and pharmacologic factors. Expand
Antidepressant-withdrawal mania:a critical review and synthesis of the literature.
  • C. Andrade
  • Psychology, Medicine
  • The Journal of clinical psychiatry
  • 2004
TLDR
The syndrome may be self-limiting, may abate with the reinstitution of the antidepressant drug, or may require specific anti-manic treatments; mood stabilizers do not necessarily protect against the syndrome. Expand
Selective serotonin reuptake inhibitors and withdrawal symptoms: a review of the literature
There are accumulating reports of withdrawal symptoms emerging following the discontinuation of selective serotonin reuptake inhibitor antidepressants. This report summarizes published reports,Expand
Loss of response to antidepressants and subsequent refractoriness: diagnostic issues in a retrospective case series.
  • V. Sharma
  • Psychology, Medicine
  • Journal of affective disorders
  • 2001
TLDR
It is suggested that some refractory depressives represent cryptic bipolar disorders and improve upon discontinuation of antidepressants and continued treatment with mood stabilizers. Expand
Treatment Approaches to Major Depressive Disorder Relapse
TLDR
The results generally support increasing dose as a first-line treatment strategy for a patient who has relapsed while taking a previously effective dose of an antidepressant. Expand
Treatment approaches to major depressive disorder relapse. Part 1: dose increase.
TLDR
The patients relapsing after initially responding to fluoxetine can benefit from an increase in fluoxettine dose, and results generally support increasing dose as a first-line treatment strategy for a patient who has relapsed while taking a previously effective dose of an antidepressant. Expand
Progressive resistance to a selective serotonin reuptake inhibitor but not to cognitive therapy in the treatment of major depression.
TLDR
If these findings are replicated in methodologically rigorous studies of paroxetine and other antidepressants, CT should be recommended, in preference to AD, for patients with multiple prior AD exposures. Expand
...
1
2
3
4
5
...