The mechanisms of tolerance in antidepressant action

@article{Fava2011TheMO,
  title={The mechanisms of tolerance in antidepressant action},
  author={G. Fava and E. Offidani},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2011},
  volume={35},
  pages={1593-1602}
}
  • G. Fava, E. Offidani
  • Published 2011
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • There is increasing awareness that, in some cases, long-term use of antidepressant drugs (AD) may enhance the biochemical vulnerability to depression and worsen its long-term outcome and symptomatic expression, decreasing both the likelihood of subsequent response to pharmacological treatment and the duration of symptom-free periods. A review of literature suggesting potential side effects during long treatment with antidepressant drugs was performed. Studies were identified electronically… CONTINUE READING

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