The mechanisms of kinesin motor motility: lessons from the monomeric motor KIF1A

@article{Hirokawa2009TheMO,
  title={The mechanisms of kinesin motor motility: lessons from the monomeric motor KIF1A},
  author={Nobutaka Hirokawa and Ryo Nitta and Yasushi Okada},
  journal={Nature Reviews Molecular Cell Biology},
  year={2009},
  volume={10},
  pages={877-884}
}
Most kinesins move processively along microtubules by using energy derived from ATP hydrolysis. Almost all of the intermediate structures of this ATPase reaction cycle have been solved for the monomeric kinesin 3 family motor KIF1A. Based on this structural information, we propose a common mechanism of kinesin motility, focusing on the regulation of kinesin motility through their interaction with microtubules and by their 'neck-linker' region, which connects their motor domain to cargo and… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 67 REFERENCES

Similar Papers

Loading similar papers…