The mechanisms of immune diversification and their disorders

  title={The mechanisms of immune diversification and their disorders},
  author={Jean-Pierre de Villartay and Alain Fischer and Anne H Durandy},
  journal={Nature Reviews Immunology},
Three molecular mechanisms contribute to the diversity of the immune repertoire of B and T cells: V(D)J recombination generates the primary repertoire in both cases, whereas class-switch recombination (CSR) and somatic hypermutation (SHM) improve the quality of the B-cell response after antigen triggering. These three mechanisms involve marked DNA damage and modification, which require a fully competent cellular DNA-repair machinery. Defects in V(D)J recombination, CSR or SHM reactions lead to… CONTINUE READING