The mechanisms of carnosic acid attenuates tumor necrosis factor-α-mediated inflammation and insulin resistance in 3T3-L1 adipocytes.

@article{Tsai2014TheMO,
  title={The mechanisms of carnosic acid attenuates tumor necrosis factor-α-mediated inflammation and insulin resistance in 3T3-L1 adipocytes.},
  author={Chia-Wen Tsai and Kai-Li Liu and Yu-Ru Lin and Wen-Cheng Kuo},
  journal={Molecular nutrition & food research},
  year={2014},
  volume={58 4},
  pages={654-64}
}
SCOPE Insulin resistance has been linked to a low-grade chronic inflammatory response. Carnosic acid (CA), which is found in rosemary, has been reported to have antioxidant, anti-inflammation, and anti-adipogenic properties. Here, we examined the effects of CA on inflammation and insulin resistance in 3T3-L1 adipocytes treated with tumor necrosis factor-α (TNF-α). METHODS AND RESULTS CA attenuated the TNF-α-induced mRNA expression of inflammatory genes, including IL-6 and monocyte… CONTINUE READING

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