The mechanisms of alloxan- and streptozotocin-induced diabetes

  title={The mechanisms of alloxan- and streptozotocin-induced diabetes},
  author={Sigurd Lenzen},
Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the GLUT2 glucose transporter. In the presence of intracellular thiols, especially glutathione, alloxan generates reactive oxygen species (ROS) in a cyclic redox reaction with its reduction product, dialuric acid. Autoxidation of dialuric acid generates superoxide radicals, hydrogen peroxide and, in a final iron-catalysed reaction step, hydroxyl radicals. These hydroxyl radicals… CONTINUE READING
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Alloxan and streptozotocin diabetes

  • S Lenzen
  • Abhandlung der Sächs. Akad. Wiss., Mathnaturwiss…
  • 2007
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Inhibition of glucokinase and hexokinase from pancreatic B-cells and liver by alloxan, alloxantin, dialuric acid, and t-butylhydroperoxide

  • S Lenzen, M Mirzaie-Petri
  • Biomed Res
  • 1991
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