The mechanisms of action of cyclosporine.

  title={The mechanisms of action of cyclosporine.},
  author={Brian M. J. Foxwell and B Ruffel},
  journal={Cardiology clinics},
  volume={8 1},
CS most probably manifests its immunosuppressive effects by inhibiting the synthesis of IL-2 and other lymphokine mRNAs during the process of T-cell activation. The detailed molecular events involved in CS's inhibition of mRNA synthesis are not known, but it is likely that the drug prevents transduction of the mitogenic signal from the cell surface to the nucleus at a point subsequent to the rise in intracellular calcium generated by the mitogenic signal. CS immunosuppression also appears to be… CONTINUE READING

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