The mechanism of vascular calcification – a systematic review

@article{Karwowski2012TheMO,
  title={The mechanism of vascular calcification – a systematic review},
  author={W. Karwowski and B. Naumnik and M. Szczepanski and M. Myśliwiec},
  journal={Medical Science Monitor : International Medical Journal of Experimental and Clinical Research},
  year={2012},
  volume={18},
  pages={RA1 - RA11}
}
Summary Calcification of vessels reduces their elasticity, affecting hemodynamic parameters of the cardiovascular system. The development of arterial hypertension, cardiac hypertrophy, ischemic heart disease or peripheral arterial disease significantly increases mortality in patients over 60 years of age. Stage of advancement and the extent of accumulation of calcium deposits in vessel walls are key risk factors of ischemic events. Vascular calcification is an active and complex process that… Expand
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References

SHOWING 1-10 OF 126 REFERENCES
Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
TLDR
Evidence has accumulated pointing to the active and regulated nature of the calcification process, responsible for stiffening of the arteries with increased left-ventricular afterload and abnormal coronary perfusion as the principal clinical consequences. Expand
Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality.
TLDR
AMC is a strong prognostic marker of all-cause and CV mortality in HD patients, independently of classical atherogenic factors and the principal effect of AMC on arterial function is increased arterial stiffness. Expand
High-Density Lipoprotein Regulates Calcification of Vascular Cells
TLDR
Results suggest that HDL regulates the osteoblastic differentiation and calcification of vascular cells and that vascular calcification may be another target of HDL action in the artery wall. Expand
Vascular calcification: pathobiology of a multifaceted disease.
TLDR
Clinically, vascular calcification is now accepted as a valuable predictor of coronary heart disease, and, conversely, many treatments for cardiovascular disease such as statins, antioxidants, hormone replacement therapy, ACE inhibitors, fish oils, and calcium channel blockers may affect bone health. Expand
Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients.
TLDR
Compared with calcium-based phosphate binders, sevelamer is less likely to cause hypercalcemia, low levels of PTH, and progressive coronary and aortic calcification in hemodialysis patients. Expand
Association of serum phosphate with vascular and valvular calcification in moderate CKD.
TLDR
Higher serum phosphate concentrations are associated with a greater prevalence of vascular and valvular calcification in people with moderate CKD, and it remains to be determined whether lowering phosphate concentrations will impact calcification risk in the setting of kidney disease. Expand
Vascular calcification: mechanisms and clinical ramifications.
TLDR
Evidence indicates that proteins controlling bone mineralization are also involved in the regulation of vascular calcification, a complex, regulated process of biomineralization resembling osteogenesis, which is widely used as a clinical indicator of atherosclerosis. Expand
Progression of Aortic Valve Calcification: Association With Coronary Atherosclerosis and Cardiovascular Risk Factors
TLDR
A strong influence of LDL cholesterol level on the progression of AVC and CC is observed, suggesting that lipid-lowering therapy may decrease the progressionof aortic valve calcification. Expand
BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells.
TLDR
It is found that treatment of SMC with BMP-2 enhanced elevated phosphate-induced calcification, but did not induce calcification under normal phosphate conditions, indicating that phosphate transport via Pit-1 is crucial in B MP-2-regulated SMC calcification. Expand
Risk factors of one year increment of coronary calcifications and survival in hemodialysis patients
TLDR
Progression of calcification is of common occurrence, with special regard to elevated basal scores, and is predictive of survival, while some classic and non classic risk factors play an important role in progression. Expand
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