The mechanism of transmembrane S-nitrosothiol transport.

@article{Zhang2004TheMO,
  title={The mechanism of transmembrane S-nitrosothiol transport.},
  author={Yanhong Zhang and N. Hogg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 21},
  pages={
          7891-6
        }
}
  • Yanhong Zhang, N. Hogg
  • Published 2004
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
S-nitrosothiols have been suggested to play an important role in nitric oxide (NO)-mediated biological events. However, the mechanisms by which an S-nitrosothiol (or the S-nitroso functional group) is transferred across cell membrane are still poorly understood. We have demonstrated previously that the degradation of S-nitrosoglutathione (GSNO) by cells absolutely required the presence of cystine in the extracellular medium and proposed a mechanism that involved the reduction of cystine to… Expand
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