The mechanism of thrombin-induced platelet factor 4 secretion.

@article{Ginsberg1980TheMO,
  title={The mechanism of thrombin-induced platelet factor 4 secretion.},
  author={Mark H. Ginsberg and L. M. Taylor and Richard G. Painter},
  journal={Blood},
  year={1980},
  volume={55 4},
  pages={
          661-8
        }
}
We have measured thrombin-induced secretion of platelet factor 4 antigen (PF4) and simultaneously followed its intracellular translocation by immunofluorescence. In permeable resting platelets, speckled intracellular immunofluorescent staining for PF4 was observed. Addition of thrombin to washed platelets at 22 degrees C resulted in secretion of PF4 and formation of large (approximately 0.5 micrometer) immunofluorescent masses. These masses moved to the cell periphery during secretion and were… 

Figures from this paper

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