The mechanism of the degradation of DNA by streptonigrin.

@article{Cone1976TheMO,
  title={The mechanism of the degradation of DNA by streptonigrin.},
  author={Richard Cone and Syed Kazim Hasan and J. William Lown and Ashley R Morgan},
  journal={Canadian journal of biochemistry},
  year={1976},
  volume={54 3},
  pages={219-23}
}
The production of single strand cleavage in covalently-closed circular-DNA by the antitumour agent streptonigrin (reduced in situ by NADH) is demonstrated using the ethidium bromide fluorescence assay described previously. The degradation dependent on oxygen is completely inhibited by superoxide dismutase (EC 1.15.1.1) suggesting the intermediacy of the superoxide radical anion in the degradation. However similar complete inhibition of DNA strand breakage by catalase (EC 1.11.1.6) indicates… CONTINUE READING
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