The mechanism of spontaneous firing in histamine neurons.

  title={The mechanism of spontaneous firing in histamine neurons.},
  author={David R. Stevens and Krister S. Eriksson and Ritchie E Brown and Helmut L. Haas},
  journal={Behavioural brain research},
  volume={124 2},
Histaminergic neurons project to virtually the whole central nervous system and display regular firing related to behavioral state. Electrophysiological studies of histaminergic neurons show that these neurons fire in a beating pacemaker pattern, which is intrinsic to individual neurons. Onset of an action potential occurs as the result of a slow depolarizing potential, which consists of voltage dependent calcium current(s) and non-inactivating sodium current. The calcium component is a voltage… CONTINUE READING

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