The mechanism of spleen injury in rabbits with acute renal failure.

@article{Zhao2011TheMO,
  title={The mechanism of spleen injury in rabbits with acute renal failure.},
  author={Zi-gang Zhao and Chun-yu Niu and Yu-ping Zhang and Rui Han and Ya-li Hou and Xiaorong Wang and Hua Jiang and Shu-ting Du and Bei Lu},
  journal={Renal failure},
  year={2011},
  volume={33 4},
  pages={418-25}
}
Immune function disorders are common during acute renal failure (ARF), but the mechanisms are unknown. As the spleen is the largest organ of the immune system, we aimed to observe if there are morphological changes in the spleen in rabbits with ARF. In addition, we tried to explore its mechanism from the perspective of oxygen free radicals, nitric oxide (NO), myeloperoxidase (MPO), and membrane pump activities. ARF animal models were established by either hypodermic injection of 1.3 mL/kg bw 1… CONTINUE READING