The mechanism of retroviral integration through X-ray structures of its key intermediates

@inproceedings{Maertens2010TheMO,
  title={The mechanism of retroviral integration through X-ray structures of its key intermediates},
  author={Goedele N Maertens and Stephen Hare and Peter Cherepanov},
  booktitle={Nature},
  year={2010}
}
To establish productive infection, a retrovirus must insert a DNA replica of its genome into host cell chromosomal DNA. This process is operated by the intasome, a nucleoprotein complex composed of an integrase tetramer (IN) assembled on the viral DNA ends. The intasome engages chromosomal DNA within a target capture complex to carry out strand transfer, irreversibly joining the viral and cellular DNA molecules. Although several intasome/transpososome structures from the DDE(D) recombinase… CONTINUE READING
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