The mechanism of oxidation of aldehydes by glyceralde-hyde-3-phosphate dehydrogenase.


It has been demonstrated (1) that the oxidation-reduction of methylglyoxal to lactic acid occurs in two steps. The first step is a condensation of methylglyoxal and reduced glutathione to a thiol ester which is hydrolytically cleaved to lactic acid and reduced glutathione. It was pointed out that such a mechanism might be operative in other aldehyde… (More)


4 Figures and Tables