The mechanism of myocyte death in ischaemia.


Mechanisms of myocyte cell death in severe ischaemia may include: (1) accumulated metabolic products; (2) activation of membrane phospholipases; (3) formation of oxygen-derived free-radicals; (4) infiltration by activated neutrophils; (5) increased circulating catecholamines; (6) cytosolic calcium overload; (7) an inadequate supply of glycolytically produced ATP. The hypothesis is proposed that failure of glycolysis leads to inadequate control of intracellular calcium, which is a lethal event. This hypothesis would explain the concept that in the hibernating myocardium, viable zones can be detected by positron emission tomography of fluoro-deoxyglucose.


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@article{Opie1993TheMO, title={The mechanism of myocyte death in ischaemia.}, author={Lionel Henry Opie}, journal={European heart journal}, year={1993}, volume={14 Suppl G}, pages={31-3} }