The mechanism of melanoma-associated thrombin activity and von Willebrand factor release from endothelial cells.

Abstract

Activation of the coagulation system in malignancy enables tumor spreading and is thus associated with poor prognosis for the patient. In this study, we analyzed the in vitro mechanisms by which two human metastatic melanoma cell lines, MV3 and WM9, transform the vascular endothelium into a prothrombotic activated state. We show that both melanoma cell… (More)
DOI: 10.1038/jid.2010.136

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