The mechanism of long-term low-dose asymmetric dimethylarginine inducing transforming growth factor-β expression in endothelial cells.

@article{Feng2013TheMO,
  title={The mechanism of long-term low-dose asymmetric dimethylarginine inducing transforming growth factor-β expression in endothelial cells.},
  author={Yiduo Feng and Dongliang Zhang and Yu Zhang and Qidong Zhang and Wenhu Liu},
  journal={International journal of molecular medicine},
  year={2013},
  volume={31 1},
  pages={67-74}
}
Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase (NOS) inhibitor, accumulates in plasma during chronic kidney disease (CKD). High plasma levels of ADMA can increase transforming growth factor-β (TGF-β) expression, related to renal fibrosis, but the precise molecular mechanism is not explicit. The present study was designed to determine the mechanism through which long-term low-dose ADMA induces TGF-β expression… CONTINUE READING