The mechanism of killing of mouse fibroblasts by the amino acid analogue 5‐fluorotryptophan

  title={The mechanism of killing of mouse fibroblasts by the amino acid analogue 5‐fluorotryptophan},
  author={Mary Taub},
  journal={Journal of Cellular Physiology},
  • M. Taub
  • Published 1 November 1977
  • Biology, Medicine
  • Journal of Cellular Physiology
The mechanism of killing of A9 fibroblasts by 5‐fluorotryptophan has been studied. L‐tryptophan competitively relieves the growth inhibition caused by 5FT. After incubation with 5FT, 3H‐5FT was incorporated into protein, replacing tryptophan residues. During the initial hours of incubation with 5FT, a specific inhibition was observed of the incorporation of L‐tryptophan into protein; later this inhibition was followed by a general inhibition of protein synthesis and cell division. However… 
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