The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.

Abstract

Insulin activation of mTOR complex 1 is accompanied by enhanced binding of substrates. We examined the mechanism and contribution of this enhancement to insulin activation of mTORC1 signaling in 293E and HeLa cells. In 293E, insulin increased the amount of mTORC1 retrieved by the transiently expressed nonphosphorylatable 4E-BP[5A] to an extent that varied… (More)
DOI: 10.1074/jbc.M111.245449

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@article{Rapley2011TheMO, title={The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.}, author={Joseph Rapley and Noriko Oshiro and Sara Ortiz-Vega and Joseph Avruch}, journal={The Journal of biological chemistry}, year={2011}, volume={286 44}, pages={38043-53} }