The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility.

Abstract

The mechanism of diltiazem-induced inhibition of smooth muscle contractility was investigated by studying its effects on tension development and Ca++ fluxes in the rabbit aorta. Diltiazem caused a dose-dependent inhibiton of contractions as well as Ca++ influx stimulated by alpha adrenoceptor activation and high-K+ depolarization. Diltiazem was roughly… (More)

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Cite this paper

@article{Breemen1981TheMO, title={The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility.}, author={Cornelius van Breemen and O Hyun Hwang and Kaushik D. Meisheri}, journal={The Journal of pharmacology and experimental therapeutics}, year={1981}, volume={218 2}, pages={459-63} }