The mechanism of inactivation of human platelet factor Va from normal and activated protein C-resistant individuals.

Abstract

The inactivation of human platelet factor Va by activated protein C (APC) was analyzed by functional assessment of cofactor activity and Western blotting analysis to visualize the factor Va fragments accompanying proteolysis. Platelets were treated with thrombin to facilitate both their activation as well as the release and further activation of platelet… (More)

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