An introduction to immunosuppressants.
- Biology, MedicineAdvances in pharmacology and chemotherapy
INDUCTION AND REVERSAL OF IMMUNE PARALYSIS IN VITRO
- Biology, MedicineThe Journal of experimental medicine
It was concluded that a reversible state of paralysis could be instituted in antigen-responsive cells, and this state did not depend upon cell-killing.
IMMUNOLOGICAL PARALYSIS TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE AS ASSESSED BY AN IMMUNO‐PLAQUE PROCEDURE
- Biology, Medicine
An adaptation of the technique of localized hemolysisin-gel that permits one to determine not only the number of antibody-forming cells produced in response to pneumococcal polysaccharides but also the rate at which antibody is synthesized and released by such cells is developed.
Suppression of the Immune Response: Reversal of the Disease State with Antigen in Allergic Encephalomyelitis
It is established that the A1 protein, the basic protein of CNS myelin (molecular weight 18,400), which comprises 30% of the myelin protein1, is the encephalitogenic agent of CNS tissue.
IMMUNOLOGICAL TOLERANCE TO INFLUENZA VIRUS IN MICE
- Biology, Medicine
This work has sought a model system whereby a relatively common and wellstudied virus, such as influenza, may be injected into neonatal animals so that possible alteration of responsiveness of the animals to subsequent injection of either living or nonliving viral material may be observed.
The significance of the dose of antien in immunity and tolerance.
- Medicine, BiologyCurrent topics in microbiology and immunology
The centre of these regulation processes appears to be the control of the molecular type of antibodies produced, which is reflected in the kinetics of the immune response and the development of immunological memory.
Thymus-independent B-cell induction and paralysis.
- BiologyAdvances in immunology
Comparison of the suppressive effect of thymus cells and the suppression by neonatal application of antigen
- Biology, MedicineEuropean journal of immunology
The suppressive effect of thymus cells on the agglutinating antibody response in chickens is shown to be antigen‐specific and strikingly resembles the phenomenon of antigen‐ specific suppression that is seen after antigenic stimulus in the prenatal or early postnatal period.
SHOWING 1-10 OF 219 REFERENCES
STUDIES ON THE INDUCTION OF IMMUNOLOGICAL UNRESPONSIVENESS TO PNEUMOCOCCAL POLYSACCHARIDE IN MICE
- Medicine, BiologyThe Journal of experimental medicine
The results suggest that the induction of polysaccharide paralysis is related to the concentration of antigen in the animal and is not modified by the number of immunologically competent cells.
Induction of immunological paralysis in two zones of dosage
- Medicine, BiologyProceedings of the Royal Society of London. Series B. Biological Sciences
An interpretation is offered in terms of concomitant immunization, in which some cells become immunized while others become paralysed, and a double threshold of paralysis, which confirms the highly specific nature of paralysis.
Immunological Tolerance as the Result of Terminal Differentiation of Immunologically Competent Cells
The solution of the problem has been transferred to the cellular level and somu authors assume that the onset of tolerance is possible at all stages of cell differentiation when antigen is present in excess.
Studies on the mechanism of the immunological paralysis induced in mice by pneumococcal polysaccharides.
- Biology, MedicineJournal of immunology
The only successful means found for counteracting the “paralysis” in mice was the use of whole-cell vaccine, and this was applicable only to type I but not to types II and III.
Studies on Pneumococcal Polysaccharide: II. Mechanism Involved in Production of “Immunological Paralysis” by Type I Pneumococcal Polysaccharide
- Biology, Medicine
Preliminary experiments indicate that mice which have been immunized by injection of an antigenic dose of SI promptly lose their immunity when given 500 μg, as would be expected if the mechanism postulated is true.
Nature and mode of action of antilymphocytic antiserum.
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
The experiments reported here are intended to throw further light on the nature and mode of action of ALS and the sensitivity aroused in CBA mice by grafts of A skin, as measured by the survival time of a second graft transplanted at various intervals after the rejection of a first graft.
Recovery from immunological paralysis in relation to age and residual antigen.
- Biology, MedicineImmunology
In harmony with this hypothesis, irradiation proved capable of deleting an existing state of paralysis without appreciably enhancing recovery, and was considered to confirm the importance of cell turnover in recovery.
Specific inhibition of antibody production. I. Protein-over loading paralysis.
- Medicine, BiologyImmunology
The degree of paralysis was found to diminish when the time between the paralysing injection and challenge injection was increased, and this loss of the paralysed state could be prevented by injections of antigen whilst the mice were still paralysed.
Initiation of Immune Responses by Small Lymphocytes
The large pyroninophilic cells that arise from small lymphocytes in graft-versus host reactions were observed to resemble morphologically the cells that appear in regional lymphoid tissue during the reaction against homo, grafts of skin and during antibody formation, suggesting that primary immune responses in general may be initiated by the interaction of antigens withSmall lymphocytes.