The mechanism of immunological paralysis.

@article{Dresser1968TheMO,
  title={The mechanism of immunological paralysis.},
  author={David W. Dresser and Neil Mitchison},
  journal={Advances in immunology},
  year={1968},
  volume={8},
  pages={
          129-81
        }
}
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It is established that the A1 protein, the basic protein of CNS myelin (molecular weight 18,400), which comprises 30% of the myelin protein1, is the encephalitogenic agent of CNS tissue.
The role of lysosomes in immune responses.
IMMUNOLOGICAL TOLERANCE TO INFLUENZA VIRUS IN MICE
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This work has sought a model system whereby a relatively common and wellstudied virus, such as influenza, may be injected into neonatal animals so that possible alteration of responsiveness of the animals to subsequent injection of either living or nonliving viral material may be observed.
The significance of the dose of antien in immunity and tolerance.
  • J. Ivanyi, J. Cerny
  • Medicine, Biology
    Current topics in microbiology and immunology
  • 1969
TLDR
The centre of these regulation processes appears to be the control of the molecular type of antibodies produced, which is reflected in the kinetics of the immune response and the development of immunological memory.
Thymus-independent B-cell induction and paralysis.
Comparison of the suppressive effect of thymus cells and the suppression by neonatal application of antigen
  • W. Droege
  • Biology, Medicine
    European journal of immunology
  • 1973
TLDR
The suppressive effect of thymus cells on the agglutinating antibody response in chickens is shown to be antigen‐specific and strikingly resembles the phenomenon of antigen‐ specific suppression that is seen after antigenic stimulus in the prenatal or early postnatal period.
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References

SHOWING 1-10 OF 219 REFERENCES
STUDIES ON THE INDUCTION OF IMMUNOLOGICAL UNRESPONSIVENESS TO PNEUMOCOCCAL POLYSACCHARIDE IN MICE
TLDR
The results suggest that the induction of polysaccharide paralysis is related to the concentration of antigen in the animal and is not modified by the number of immunologically competent cells.
Induction of immunological paralysis in two zones of dosage
  • N. Mitchison
  • Medicine, Biology
    Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1964
TLDR
An interpretation is offered in terms of concomitant immunization, in which some cells become immunized while others become paralysed, and a double threshold of paralysis, which confirms the highly specific nature of paralysis.
Immunological Tolerance as the Result of Terminal Differentiation of Immunologically Competent Cells
TLDR
The solution of the problem has been transferred to the cellular level and somu authors assume that the onset of tolerance is possible at all stages of cell differentiation when antigen is present in excess.
Transplantation Immunity and Tolerance
Studies on the mechanism of the immunological paralysis induced in mice by pneumococcal polysaccharides.
TLDR
The only successful means found for counteracting the “paralysis” in mice was the use of whole-cell vaccine, and this was applicable only to type I but not to types II and III.
Studies on Pneumococcal Polysaccharide: II. Mechanism Involved in Production of “Immunological Paralysis” by Type I Pneumococcal Polysaccharide
  • S. Ok
  • Biology, Medicine
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TLDR
Preliminary experiments indicate that mice which have been immunized by injection of an antigenic dose of SI promptly lose their immunity when given 500 μg, as would be expected if the mechanism postulated is true.
Nature and mode of action of antilymphocytic antiserum.
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  • 1966
TLDR
The experiments reported here are intended to throw further light on the nature and mode of action of ALS and the sensitivity aroused in CBA mice by grafts of A skin, as measured by the survival time of a second graft transplanted at various intervals after the rejection of a first graft.
Recovery from immunological paralysis in relation to age and residual antigen.
TLDR
In harmony with this hypothesis, irradiation proved capable of deleting an existing state of paralysis without appreciably enhancing recovery, and was considered to confirm the importance of cell turnover in recovery.
Specific inhibition of antibody production. I. Protein-over loading paralysis.
TLDR
The degree of paralysis was found to diminish when the time between the paralysing injection and challenge injection was increased, and this loss of the paralysed state could be prevented by injections of antigen whilst the mice were still paralysed.
Initiation of Immune Responses by Small Lymphocytes
TLDR
The large pyroninophilic cells that arise from small lymphocytes in graft-versus host reactions were observed to resemble morphologically the cells that appear in regional lymphoid tissue during the reaction against homo, grafts of skin and during antibody formation, suggesting that primary immune responses in general may be initiated by the interaction of antigens withSmall lymphocytes.
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