The mechanism of fatty acid uptake by heart mitochondria: An acylcarnitine‐carnitine exchange

@article{Ramsay1975TheMO,
  title={The mechanism of fatty acid uptake by heart mitochondria: An acylcarnitine‐carnitine exchange},
  author={Rona R. Ramsay and Philip K. Tubbs},
  journal={FEBS Letters},
  year={1975},
  volume={54}
}
Carnitine and carnitine esters in mitochondrial metabolism and function
Under physiological conditions, myocardial energy production is almost entirely dependent on mitochondrial oxidative phosphorylation [1]. At rest, in the post-absorptive state, the major fuel for
The Roleof Acyltransferasesin Fatty Acid Utilization
TLDR
Glycerophosphate and carnitine as competing acyl acceptors and the oxidation of different long chain acylcarnitines in isolated mitochondria have been investigated, and Carnitine esters of C22'fatty acids are more slowly oxidized compared to palmitylcarnitine in heart than in liver mitochondria.
The Mitochondrial Carnitine Acyl-carnitine Carrier (SLC25A20): Molecular Mechanisms of Transport, Role in Redox Sensing and Interaction with Drugs
TLDR
A large set of data on structure/function relationships have been obtained, giving novel information on the molecular mechanism of the transport catalyzed by this protein, using combined approaches of site-directed mutagenesis with chemical targeting and bioinformatics.
Accumulation of carnitine esters of beta-oxidation intermediates during palmitate oxidation by rat-liver mitochondria.
TLDR
The accumulation of carnitine esters of C6-C14 intermediates can quantitatively explain the high specific activity of the acetyl-CoA pool during the state-4 oxidation of [1(-14)C] palmitate.
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