The mechanism of cytolytic and cytostatic activity of benfluron.

  title={The mechanism of cytolytic and cytostatic activity of benfluron.},
  author={Katar{\'i}na Hor{\'a}kov{\'a} and Drahom{\'i}ra Luk{\'a}cov{\'a} and J Koz{\'a}nkov{\'a} and Andrej D{\vz}urba and Attila Ziegelh{\"o}ffer and Soňa Jantov{\'a}},
  volume={35 2},
Benfluron at concentrations of 0.26 and 0.52 mumol l-1 inhibited the formation of V79 colonies in a concentration-dependent way. Diminution of the size of colonies of the treated cells was accompanied by a decrease in protein content per cell. At the same time an increase in metabolic activity was observed. Benfluron blocked the V79 cells in S and G2 phases of the cell cycle and at higher concentrations induced cell lysis documented by alterations in cell membrane permeability and morphology… CONTINUE READING