The mechanism of collapse of heterogeneous lipid monolayers.

  title={The mechanism of collapse of heterogeneous lipid monolayers.},
  author={Svetlana Baoukina and Dmitri Rozmanov and Eduardo Mendez-Villuendas and D. Peter Tieleman},
  journal={Biophysical journal},
  volume={107 5},
Collapse of homogeneous lipid monolayers is known to proceed via wrinkling/buckling, followed by folding into bilayers in water. For heterogeneous monolayers with phase coexistence, the mechanism of collapse remains unclear. Here, we investigated collapse of lipid monolayers with coexisting liquid-liquid and liquid-solid domains using molecular dynamics simulations. The MARTINI coarse-grained model was employed to simulate monolayers of ∼80 nm in lateral dimension for 10-25 μs. The monolayer… CONTINUE READING