The mechanism of axon growth: what we have learned from the cell adhesion molecule L1.

@article{Kamiguchi2003TheMO,
  title={The mechanism of axon growth: what we have learned from the cell adhesion molecule L1.},
  author={Hiroyuki Kamiguchi},
  journal={Molecular neurobiology},
  year={2003},
  volume={28 3},
  pages={219-28}
}
Cell adhesion molecules (CAMs) are not just an inert glue that mediates static cell-cell and cell-extracellular matrix (ECM) adhesion; instead, their adhesivity is dynamically controlled to enable a cell to migrate through complex environmental situations. Furthermore, cell migration requires distinct levels of CAM adhesivity in various subcellular regions. Recent studies on L1, a CAM in the immunoglobulin superfamily, demonstrate that cell adhesion can be spatially regulated by the polarized… CONTINUE READING

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