The mechanism of alphaIIbbeta3 antagonism by savignygrin and its implications for the evolution of anti-hemostatic strategies in soft ticks.

@article{Mans2004TheMO,
  title={The mechanism of alphaIIbbeta3 antagonism by savignygrin and its implications for the evolution of anti-hemostatic strategies in soft ticks.},
  author={B. Mans and A. Neitz},
  journal={Insect biochemistry and molecular biology},
  year={2004},
  volume={34 6},
  pages={
          573-84
        }
}
  • B. Mans, A. Neitz
  • Published 2004
  • Medicine
  • Insect biochemistry and molecular biology
Savignygrin, a alphaIIbbeta3 antagonist presents the RGD sequence on the substrate-binding loop of the (BPTI-fold). This study investigated whether this is the only integrin-targeting motif associated with its mechanism. It forms a tight-binding complex with alphaIIbbeta3 that is resistant to SDS dissociation under reducing and non-reducing conditions, but not to temperature or EDTA. The same complex is formed on resting and activated platelets, as well as aggregated platelets that have been… Expand
rLj-RGD 4 , an RGD toxin protein from Lampetra japonica , can inhibit proliferation and migration of human laryngeal squamous carcinoma Hep-2 cells
rLj-RGD4, the recombinant Lampetra japonica (Arg-Gly-Asp) 4, is a recombinant soluble version of the wild-type rLj-RGD3 protein found in the salivary gland of Lampetra japonica, which isExpand
An insight into the salivary transcriptome and proteome of the soft tick and vector of epizootic bovine abortion, Ornithodoros coriaceus.
TLDR
The results indicate that each genus of hematophagous arthropods studied to date evolved unique protein families that assist blood feeding, thus characterizing potentially new pharmacologically active components or antimicrobial agents. Expand
Ancestral reconstruction of tick lineages.
TLDR
An attempt is made to delineate the current knowledge with regard to the ancestral reconstruction of the tick (Ixodida) lineage, indicating modification with descent, as expected for Darwinian evolutionary theory. Expand