The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism.

@article{Sztrolovics2002TheMO,
  title={The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism.},
  author={Robert Sztrolovics and Robert J. White and Peter J. Roughley and John S. Mort},
  journal={The Biochemical journal},
  year={2002},
  volume={362 Pt 2},
  pages={465-72}
}
The mechanisms of aggrecan degradation in adult human articular, adult bovine nasal and fetal bovine epiphyseal cartilage in response to either interleukin-1beta (IL-1beta) or retinoic acid were compared using an explant culture system. Bovine nasal cartilage cultured with either IL-1beta or retinoic acid exhibited significant release of glycosaminoglycan… CONTINUE READING