The mechanism of ageing: primary role of transposable elements in genome disintegration

@article{Sturm2015TheMO,
  title={The mechanism of ageing: primary role of transposable elements in genome disintegration},
  author={{\'A}d{\'a}m Sturm and Zolt{\'a}n Ivics and Tibor Vellai},
  journal={Cellular and Molecular Life Sciences},
  year={2015},
  volume={72},
  pages={1839-1847}
}
Understanding the molecular basis of ageing remains a fundamental problem in biology. In multicellular organisms, while the soma undergoes a progressive deterioration over the lifespan, the germ line is essentially immortal as it interconnects the subsequent generations. Genomic instability in somatic cells increases with age, and accumulating evidence indicates that the disintegration of somatic genomes is accompanied by the mobilisation of transposable elements (TEs) that, when mobilised, can… Expand
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