The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine.

@article{Lenkey2006TheMO,
  title={The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine.},
  author={Nora Lenkey and Robert Karoly and J{\'a}nos P{\'e}ter Kiss and Bernadett K. Sz{\'a}sz and E. Sylvester Vizi and Arpad Mike},
  journal={Molecular pharmacology},
  year={2006},
  volume={70 6},
  pages={
          2052-63
        }
}
  • Nora Lenkey, Robert Karoly, +3 authors Arpad Mike
  • Published in Molecular pharmacology 2006
  • Chemistry, Medicine
  • The effect of monoamine uptake inhibitor-type antidepressants on sodium channels of hippocampal neurons was investigated. Members of the tricyclic group of antidepressants are known to modify multiple targets, including sodium channels, whereas selective serotonin-reuptake inhibitors (SSRIs) are regarded as highly selective compounds, and their effect on sodium channels was not investigated in detail. In this study, a representative member of each group was chosen: the tricyclic antidepressant… CONTINUE READING

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