The mechanism of action of the tumour suppressor gene PTEN.

Abstract

Intracellular levels of phosphorylation are regulated by the coordinated action of protein kinases and phosphatases. Disregulation of this balance can lead to cellular transformation. Here we review knowledge of the mechanisms of one protein phosphatase, the tumour suppressor PTEN/MMAC/TEP 1 apropos its role in tumorigenesis and signal transduction. PTEN… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.