The mechanism of action of methotrexate.

  title={The mechanism of action of methotrexate.},
  author={Bruce Cronstein},
  journal={Rheumatic diseases clinics of North America},
  volume={23 4},
  • Bruce Cronstein
  • Published 1997 in Rheumatic diseases clinics of North America
Because of methotrexate's well-documented efficacy in the treatment of rheumatoid arthritis, it is important that we understand the mechanism of action of this drug. There are two biochemical mechanisms by which methotrexate may modulate inflammation: (1) promotion of adenosine release and (2) inhibition of transmethylation reactions. Evidence is reviewed that favors the notion that the endogenous anti-inflammatory autocoid adenosine mediates the anti-inflammatory effects of methotrexate. This… CONTINUE READING

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