The mechanism of action of local anesthesia by tetraethylammonium derivatives.

@article{Curtis1981TheMO,
  title={The mechanism of action of local anesthesia by tetraethylammonium derivatives.},
  author={B M Curtis and J E Scurlock},
  journal={Anesthesiology},
  year={1981},
  volume={54 4},
  pages={270-7}
}
Tetraethylammonium (TEA+) derivatives in which one of the ethyl groups is replaced by a longer chain alkane (C4-C16) were tested for their ability to block the compound action potential (CAP) of frog sciatic nerve. A parabolic relation between chain length and 100 per cent blocking dose was found, suggesting an optimal size of C12 for the inhibitory receptor. Two types of inhibition were observed. Type 1 was an inhibition of the CAP at all frequencies when the nerve was perfused with the TEA… CONTINUE READING