The mechanism of action of PA-824: Novel insights from transcriptional profiling.

@article{Manjunatha2009TheMO,
  title={The mechanism of action of PA-824: Novel insights from transcriptional profiling.},
  author={Ujjini H Manjunatha and Helena I. M. Boshoff and Clifton E Barry},
  journal={Communicative & integrative biology},
  year={2009},
  volume={2 3},
  pages={215-8}
}
The bicyclic nitroimidazole PA-824 is a pro-drug with a very complex mechanism of action active against both replicating and hypoxic, non-replicating Mycobacterium tuberculosis. Microarray analysis of the mode of action of PA-824 showed a puzzling mixed effect both on genes responsive to both cell wall inhibition (like isoniazid) and respiratory poisoning… CONTINUE READING