The mechanism of acidic pH-induced contraction in aortae from SHR and WKY rats enhanced by increasing blood pressure.

@article{Furukawa1996TheMO,
  title={The mechanism of acidic pH-induced contraction in aortae from SHR and WKY rats enhanced by increasing blood pressure.},
  author={K I Furukawa and J Komaba and Hiroshi Sakai and Yasushi Ohizumi},
  journal={British journal of pharmacology},
  year={1996},
  volume={118 3},
  pages={485-92}
}
1. Effect of pH on vascular smooth muscle contraction was analyzed by use of biochemical and pharmacological techniques. 2. In the aorta isolated from spontaneously hypertensive rats (SHR) decreasing extracellular pH (pH0) caused a rapid acidification of intracellular pH accompanied by a pH0-dependent increase in tension. The contraction of the SHR aorta… CONTINUE READING